15 Credits ACADEMIC YEAR



Aims/Description: TThe module examines in detail the mechanisms that maintain genome integrity and generate genetic variation, both of which are essential to eukaryotic life. The lectures illustrate how preventing and creating changes in DNA make use of the same biochemical machinery. The main emphasis is on eukaryotes, reference is made to prokaryotes mainly as an aid to understanding the importance of conserved processes. Mechanisms studied in detail include single-strand break repair, protein-linked DNA break repair, homologous and non-homologous recombination, avoidance of replication errors, mismatch repair, excision repair and mutagenesis. Throughout the module experimental detail is included to illustrate how conclusions on gene function and interactions have been determined.

Restrictions on availability: Normally available only to PG students in MBB

Staff Contact: EL-KHAMISY SHERIF
Teaching Methods: Lectures, Tutorials, Independent Study
Assessment: Formal Exam
WebCT resources are available for this module

Information on the department responsible for this unit (Molecular Biology and Biotechnology):

Departmental Home Page
Teaching timetable

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NOTE
The content of our courses is reviewed annually to make sure it's up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption.

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Teaching methods and assessment displayed on this page are indicative for 2021-22. Students will be informed by the academic department of any changes made necessary by the ongoing pandemic.

Western Bank, Sheffield, S10 2TN, UK