10 Credits SPRING


Pre-requisites: MBB266


Aims/Description: This module examines the mechanisms employed by proteins to adopt unique functional folds and explores the causes and consequences of mis-folding, with a particular reference to neurodegenerative disease, including Alzheimer's, Parkinson's and prion diseases. Students will have an opportunity to acquire knowledge and understanding of the following: methods used to study the assembly of protein complexes; folding of molecules: background thermodynamics; folding pathways; investigating intermediates; kinetic labelling; mutagenesis; modules of folding; the role of disulphide bonds; accessory proteins; isomerases; rotamases; chaperones. Protein mis-assembly: off-pathway species, aggregation, amyloids, accessory proteins, chaperones and disaggregases. Control of protein folding and mis-folding in vivo: recognition of unfolded protein, the UPR or unfolded protein response, proteostasis, and the role of the ubiquitin-proteasome system.

Staff Contact: STANIFORTH ROSEMARY A
Teaching Methods: Lectures, Independent Study
Assessment: Formal Exam

Information on the department responsible for this unit (Molecular Biology and Biotechnology):

Departmental Home Page
Teaching timetable

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NOTE
The content of our courses is reviewed annually to make sure it's up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption.

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Teaching methods and assessment displayed on this page are indicative for 2021-22. Students will be informed by the academic department of any changes made necessary by the ongoing pandemic.

Western Bank, Sheffield, S10 2TN, UK