10 Credits AUTUMN

Pre-requisites: MAT1510, MAT1520

MAT1510, MAT1520

Aims/Description: This course builds on the knowledge gained in MAT1520 and expands the range of biological systems covered that are core to the Cell and Human Biology element of the Materials Science and Engineering (Biomaterials) and Bioengineering courses. The following are included: the extracellular matrix; cell adhesion and spreading; cell communication and signalling; cytokines and HIV: complement activation and development of new biomaterials to improve biocompatibility; toxicity and toxicology including information on mutagenic effects, teratomas, carcinogens and neurotoxicity; classification of tumours, spread of tumours and clinical relevance. Two practical classes cover hands-on in vitro cell culture and toxicity testing of biomaterials. This unit aims to: Further investigate (following on from MAT1510) the extracellular matrix and its many functions; Investigate cell adhesion and spreading and how they are influenced by the physico-chemical characteristics of the underlying substrata; Provide an introduction to cell communication and cell-signalling, including information on hormones, local mediators, contact-dependent signalling molecules, and neurotransmitters; Further explore (following on from MAT1520) the biological defences available at the cellular and systems level to injury, infection and materials; Provide a detailed knowledge of toxicity and toxicology, including information on mutagenic effects, teratomas, carcinogens and neurotoxicity.

Teaching Methods: Lectures, Tutorials, Laboratory work, Independent Study
Assessment: Course work

Information on the department responsible for this unit (Materials Science and Engineering):

Departmental Home Page
Teaching timetable


The content of our courses is reviewed annually to make sure it's up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption.

URLs used in these pages are subject to year-on-year change. For this reason we recommend that you do not bookmark these pages or set them as favourites.

Teaching methods and assessment displayed on this page are indicative for 2021-22. Students will be informed by the academic department of any changes made necessary by the ongoing pandemic.

Western Bank, Sheffield, S10 2TN, UK