15 Credits SPRING



Aims/Description: The unit will be a practical, laboratory based course in which students will learn to culture human embryonic stem (hES) cells and their malignant equivalent, embryonal carcinoma cells. The course will be an intensive two week programme in which students will maintain cultures of hES cells, and carry out experiments to determine the expression of marker antigens and genes used to identify the stem cells and monitor their differentiation. They will learn and apply techniques for genetic manipulation of hES cells, and methods for inducing their differentiation. The practical work will be supplemented by lectures directly linked to specific practical sessions.The module will teach students the basis of small molecule and functional genetic screens, focusing on human disease. Students will learn about the theory and practice of automated small molecule and genetic screens. Examples of screening methods that will be covered include traditional small molecule screens, modern functional genomics and high throughput phenotypic screens. The emphasis will be to appreciate every step that is involved in this process, from automation to analysis. The student will learn how the biotech, academic and pharmaceutical industry use these techniques to identify new candidates for potential therapies. The emphasis throughout will be to appreciate how experimental research can be used to identify candidate target genes for drug discovery and small molecules, reflecting the University's mission

Staff Contact: BROWN STEPHEN
Teaching Methods: Lectures, Tutorials, Problem solving, Laboratory work, Independent Study
Assessment: Formal Exam, Course work

Information on the department responsible for this unit (Biomedical Science):

Departmental Home Page
Teaching timetable

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NOTE
The content of our courses is reviewed annually to make sure it's up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption.

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Teaching methods and assessment displayed on this page are indicative for 2021-22. Students will be informed by the academic department of any changes made necessary by the ongoing pandemic.

Western Bank, Sheffield, S10 2TN, UK