10 Credits AUTUMN

Co-requisites: MED6002, MED6005, MED6006

Aims/Description: The study of polygenic human diseases is now progressing rapidly. Although polygenic diseases are more common than single-gene disorders, studies of monogenic diseases provide an opportunity to learn about underlying molecular mechanisms, contributing to our understanding of all forms of genetic disease. In this module we will explain different ways to study human genetic diseases, and then focus on various disorders that have polygenic, chromosomal and monogenic contributions. The student will be able to see how disease mechanisms can be shared, and will learn to identify pathways that have led to the identification of gene targets for drug development. Students will explore the literature that relates to the disorders that are discussed in class so that they can propose appropriate experimental approaches to explore the genetics of other disorders.

Teaching Methods: Students attend 20 lectures and 4 tutorials, each of 50 minutes. Students will spend a further 73 hours in background study. O1, O2, O3 Lectures will present a number of clinical disorders that are currently understood to have a variety of different types and levels of genetic contributions to their aetiology. Lectures will focus on the types of evidence that have supported these conclusions. Lecturers will provide references that will allow students to review the evidence, in private study. O2 Students will review the examples that have been presented and in advance of two tutorials and will apply their learned skills to analyse the evidence available for further example diseases. O3 Students will be asked, in advance of two tutorials, to propose a genetic study or propose to extend existing studies to extend our understanding of the genetic contributions of example diseases.
Assessment: Course work

Information on the department responsible for this unit (Infection, Immunity and Cardiovascular Disease):

Teaching timetable


The content of our courses is reviewed annually to make sure it's up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption.

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Teaching methods and assessment displayed on this page are indicative for 2021-22. Students will be informed by the academic department of any changes made necessary by the ongoing pandemic.

Western Bank, Sheffield, S10 2TN, UK