10 Credits SPRING

Pre-requisites: MBB263

Aims/Description: Infectious diseases account for the majority of deaths worldwide. This will continue to be the case until we have a greater understanding of the mechanisms of microbial pathogenesis. This course builds on the principles introduced in level 2 microbiology and begins by showing how molecular genetic approaches are being used to unravel the complexities of microbial virulence. Following an introduction to the regulation of virulence genes, the pathogenic mechanisms of selected bacterial pathogens are explored in detail, demonstrating the involvement of multiple virulence determinants and their genetic regulation in the disease process. Mechanisms by which toxins deregulate or kill host cells will be explored. Virulence mechanisms that represent common themes in bacterial pathogenesis will be highlighted. The appearance of antibiotic resistant strains and strategies adopted to tackle this problem will also be considered.

Staff Contact: FAGAN ROBERT
Teaching Methods: Lectures, Independent Study
Assessment: Formal Exam
WebCT resources are available for this module

Information on the department responsible for this unit (Molecular Biology and Biotechnology):

Departmental Home Page
Teaching timetable


The content of our courses is reviewed annually to make sure it's up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption.

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Teaching methods and assessment displayed on this page are indicative for 2021-22. Students will be informed by the academic department of any changes made necessary by the ongoing pandemic.

Western Bank, Sheffield, S10 2TN, UK