Aims/Description: This module builds upon CHM2204 to extend your knowledge of some more advanced aspects of organic chemistry. The application of frontier molecular orbital theory in organic chemistry to rationalise configuration, conformation and reactivity will be illustrated. The qualitative and quantitative analysis of organic reaction mechanisms and reactivity will be described, and systematic methods to characterise transition states and high energy intermediates will be highlighted. The synthesis of cyclic compounds containing one or more heteroatoms is addressed. Saturated, unsaturated and particularly aromatic heterocyclic compounds will be discussed, and their properties and characteristic reactivities compared and contrasted. This module then develops organic synthetic analysis using the retrosynthetic approach. It will introduce novel reagents and methods which allow the synthesis of organic molecules to be devised using less obvious but highly economical transformations. The elaboration of aromatic compounds is addressed. Electrophilic and nucleophilic aromatic substitution and metalation processes will be discussed.

Staff Contact: Prof N H Williams
Teaching Methods: Lectures, Problem solving, Independent Study
Assessment: Formal Exam, Course work

Information on the department responsible for this unit (Chemistry):

Departmental Home Page
Teaching timetable


The content of our courses is reviewed annually to make sure it's up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption.

URLs used in these pages are subject to year-on-year change. For this reason we recommend that you do not bookmark these pages or set them as favourites.

Teaching methods and assessment displayed on this page are indicative for 2021-22. Students will be informed by the academic department of any changes made necessary by the ongoing pandemic.

Western Bank, Sheffield, S10 2TN, UK